Eurycomanone was inactive against murine lymphocytic leukemia (P-388) but was significantly lively towards the human cell traces examined. Two additional isolates, the beta-carboline alkaloids beta-carboline-1-propionic acid and seven-methoxy-beta-carboline-1-propionic acid, were not significantly lively with these cultured cells. However, compounds 5 and seven had been found to reveal vital antimalarial exercise as judged by research conducted with cultured Plasmodium falciparum strains. The constructions of the novel compounds 2-4 and 7 were established by spectral and chemical strategies. Antioxidant exercise and hepatoprotective potential of Phyllanthus niruri, a extensively used medicinal plant, have been investigated.
The conventional elements of Indonesia are influenced by many nations. This is due to Indonesian geographical and historical connections with some countries such because the Malay Peninsula, India, Middle East, China, and Europe. Food texture is a primary attribute of Indonesian meals since it tremendously contributes to the style and general characteristics of foods.
Antioxidant compounds were identified by Thin Layer Chromatography (TLC)–autographic assay utilizing zero.02% 1,1-diphenyl-2-picrylhydrazyl (DPPH) solution. Antioxidant activity was analyzed utilizing DPPH methodology, whereas antibacterial activity was evaluated utilizing TLC-bioautographic and agar disc diffusion methods. The outcomes showed that antioxidant compounds had been found in all fractions, with the highest chemical constituents was in dichloromethane fraction. The antioxidant activity of dichloromethane fraction was the best of all fractions with IC50 worth of 95.83±19.sixty four µg/mL, whereas ethyl acetate fraction was the bottom activity with IC50 value of 174.fifty six±21.93 µg/mL. The antibacterial assay indicated that water fraction could inhibit Escherichia coli development with inhibition diameter zone (IDZ) of two.36±1.11 mm.
Only 14-deoxyandrographolide and 14-deoxy-11,12-didehydroandrographolide exhibited cytotoxic activities (primarily based on EC50 values), however this was limited to the T-47D cell line (EC50 values of 2.eight µg/ml and 1.5 µg/ml, respectively). By bioactivity-directed fractionation, five cytotoxic constituents have been characterised from the roots of Eurycoma longifolia collected in Kalimantan, Indonesia. Four canthin-6-one alkaloids, specifically, 9-methoxycanthin-6-one, 9-methoxycanthin-6-one-N-oxide, 9-hydroxycanthin-6-one, and 9-hydroxycanthin-6-one-N-oxide, and one quassinoid, eurycomanone, were found to be cytotoxic ideas. The canthin-6-ones 1-4 were discovered to be energetic with all cell lines tested except for the KB-V1 cell line.
Tempeh, tahu (tofu), and kecap (soy sauce) are the widespread soy‐based mostly protein sources consumed, they usually play vital roles in Indonesian diets. The development of jamu as useful foods has been vigorously promoted by the Indonesian government. This research was conducted to find out antioxidant and antibacterial activities of several fractions from Crescentia cujete L. The powdered stem bark of this plant was extracted by ethanol solvent and then separated by liquid-liquid extraction. The outcomes of this separation had been n-hexane, dichloromethane, ethyl acetate, and water fractions.
The cytotoxic actions of a number of diterpenoid constituents of the medicinal plant, “hempedu bumi,” or Andrographis paniculata. The seven diterpenoid compounds used have been andrographolide, 14-deoxyandrographolide, andrographiside, deoxyandrographiside, 14-deoxy-12-methoxyandrographolide, neoandrographolide, and 14-deoxy-11,12-didehydroandrographolide. Cell survival was measured utilizing the MTS assay after seventy two h of incubation. Andrographolide, neoandrographolide, andrographiside, deoxyandrographiside, and 14-deoxy-12-methoxyandrographolide gave the impression to be noncytotoxic towards all of the cell strains.
St. John’s wort Wild-rising with yellow flowers, this herb has been used for hundreds of years in the therapy of psychological issues. Today, it is a popular advice for mild to moderate despair. Herbal supplements can interact with typical medicines or have strong effects.
Goldenseal This herb, native to America, is popular for its healing properties and antiseptic, or germ-stopping, qualities. Often used for colds and flu, additionally it is in style for soothing the nostril lining when it is inflamed or sore. Green tea This herb is used to combat fatigue, stop arteriosclerosis and sure cancers, decrease ldl cholesterol, and aid in weight loss. Hawthorn Hawthorn is popularly used for a number of heart-associated conditions and is supportive within the therapy of angina, atherosclerosis, heart failure, and high blood pressure. Saw palmetto Saw palmetto could also be used for enlarged prostate, a standard condition in men over age 50.
Methanolic and aqueous extract of leaves and fruits of P. niruri confirmed inhibition of membrane lipid peroxidation (LPO), scavenging of 1,1-diphenyl-2picrylhydrazyl (DPPH) radical and inhibition of reactive oxygen species (ROS) in vitro. Antioxidant exercise of the extracts have been also demonstrable in vivo by the inhibition of the carbon tetrachloride (CCl4) – induced formation of lipid peroxides within the liver of rats by pretreatment with the extracts.
Indonesian diets are excessive in fiber and carbohydrates with a dietary pattern of low protein and excessive carb intake. The traditional food regimen pattern has been shifted significantly toward extra consumption of fats and sugar content material foods due to the demand of convenience foods, urbanization, the increase in household incomes, and altering lifestyle.